Prisco's Week 10 NFL picks: Giants over Commanders on 'TNF,' Lions top Patriots in Munich

Prisco has laid out his full Week 10 card, and the headline calls out three of the most eye-catching selections. He is backing the Giants over the Commanders on “TNF,” siding with the Lions against the Patriots in Munich, and picking the Packers to spoil Kirk Cousins’ return with the Vikings.

Weekly pick columns are part forecast, part conversation starter. They invite fans to weigh matchups, momentum and travel quirks, and Week 10 brings all of that into focus. A Thursday night game can tilt on short rest, while an international game adds another layer because teams must handle a different setting and routine.

The Munich matchup gives the Lions and Patriots a stage that sits well outside the usual Sunday rhythm. Games played overseas often draw attention for the logistics as much as the football, with players adjusting to travel and timing before the first snap. A pick in that setting is never just about the teams on paper; it is also about how each side adapts.

Prisco’s choice of the Packers in a game tied to Kirk Cousins’ return adds another familiar NFL wrinkle: the narrative of a reunion. Those games can carry extra interest because they give fans a reason to watch beyond the standings and score line. The broader question is whether the moment changes the edge on the field, or whether the result still comes down to execution.

For fans, the appeal is simple. A Week 10 picks slate sets up a debate before the games even begin, and these three selections already frame some of the weekend’s biggest talking points.